Sci. Adv. Today 2 (2016) 25233  
  Review Article  
   
   
         
Nanostimulation of mesenchymal stem cells: At the crossroad between regenerative medicine and nanomedicine  
  Claudia Giachino and Lisa Accomasso  
     
Department of Clinical and Biological Sciences, University of Turin Regione Gonzole 10, 10043 Orbassano (Turin), Italy
   
  Abstract  
  Tissue regeneration using stem cells (SCs) and nanoengineering are exciting fields that have enormous potentials to revolutionise medicine as we know it today. In their natural microenvironment SCs are subjected to several mechanical forces acting at the nanoscale. In addition to this, nanoscale stimuli deriving from matrix architecture and stiffness play pivotal roles in directing cellular activities. The use of nanotechnology is thus an attractive and effective way to control and direct biological events for regenerative purposes. Mesenchymal stem or stromal cells (MSCs) demonstrate great potentials for regenerative approaches. They sense and respond to applied nanostimuli through a finely regulated mechanotransduction signalling machinery. This review covers the potential of nanotechnology approaches towards regenerative medicine. Knowledge of the current aspects of MSC-substratum interactions that is crucial to the understanding of many fundamental biological questions and to regenerative medicine is reported. Furthermore, this review focuses on some of the most recent applications of nanostructured materials that drive the commitment of adult MSCs for potential clinical applications. A critical reflection of the current status and future challenges of this new nano-regenerative medicine field are discussed as a conclusion to the review.  
     
   
  Cite this article as:  
  Claudia Giachino and Lisa Accomasso, Nanostimulation of mesenchymal stem cells: At the crossroad between regenerative medicine and nanomedicine, Sci. Adv. Today 2 (2016) 25233.