Sci. Adv. Today 3 (2017) 25272  
  Research Article  
   
   
         
Interfacially polymerized polyaniline/graphene oxide nanocomposite platform for the voltammetric quantification of antimycotic terbinafine  
  Ab Lateef Khan, Apresh Premi and Rajeev Jain  
     
School of Studies in Chemistry, Jiwaji University, Gwalior – 474011, India
   
  Abstract  
  Polyaniline (PANI) and graphene oxide (GRO) were polymerized interfacially to develop a PANI/GRO nanocomposite platform for the voltammetric analysis of an Antimycotic drug Terbinafine (TBF). The synthesized material was first characterized by infrared, Raman and electrochemical impedance spectroscopy, square wave and cyclic voltammetry. Also, the morphological characterization of the fabricated polymer nanocomposite was carried out by scanning electron microscopy (SEM). The amalgamated material along with the bare glassy carbon (GC), polyaniline (PANI) and graphene oxide (GRO) modified electrodes were furthermore characterized electrochemically to study the electrode kinetics by determining the effective heterogeneous electron transfer (HET) rate constant, k0eff using cyclic voltammetry. HET rate constant, k0eff studies were carried out by using inner-sphere and outer-sphere redox probes, i.e. potassium ferricyanide (III) and hexaammineruthenium (III) chloride. The synthesized material was then applied to carry out the electroanalytical studies of the Terbinafine (TBF); an antimycotic drug which under optimized experimental conditions shows the linear response for TBF for its oxidation over a concentration range from 1.00 µg mL-1 to 3.00 µg mL-1 with a correlation coefficient of 0.9950 (r2), a detection limit of 1.98 ng mL-1 and the quantification limit of 6.61 ng mL-1. The synthesized nanocomposite shows a superb performance for detection of TBF with reproducibility of 3.88% relative standard deviation (RSD).  
     
   
  Cite this article as:  
  Ab Lateef Khan, Apresh Premi and Rajeev Jain, Interfacially polymerized polyaniline/graphene oxide nanocomposite platform for the voltammetric quantification of antimycotic terbinafine, Sci. Adv. Today 3 (2017) 25272.