Sci. Adv. Today 2 (2016) 25250  
  Research Article  
   
   
         
Dramatic enhancement of enantiomer differentiation induced by chiral nanoplasmons  
  Fan Baia, Wai-Fung Laua, Lin Yanga, V. A. L. Roye,f, Zhifeng Huanga-d  
     
a Department of Physics, b Institute of Advanced Materials, c Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University (HKBU), Kowloon Tong, Kowloon, Hong Kong SAR, China
d HKBU Institute of Research and Continuing Education, 9F, the Industrialization Complex of Shenzhen Virtual University Park, No.2 Yuexing 3rd Road, South Zone, Hi-tech Industrial Park, Nanshan District, Shenzhen, Guangdong, China
e Department of Physics and Materials Science, f Center of Super-Diamond and Advanced Films, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Kowloon, Hong Kong SAR, China

   
  Abstract  
  It is necessary and challenging to sensitively differentiate an enantiomer from its mirror image, and we devise a chiral nanoplasmon-assisted method toward tackling the problem. Glutathione (GSH, with L- and D-configuration) is chemically grafted on silver nanospirals (AgNSs), leading to a weakening of chiroptical activity of an AgNS array in the visible region. The chiroptical weakening sensitively varies with the absolute configuration of GSH, resulting in a differentiation of L- and D-GSH with a AgNS-induced anisotropic g factor of ~0.5 that is independent on the AgNS helicity. The AgNS-induced anisotropy g factor is superior to those obtained by other methods, by 2-4 orders of magnitude. It is the largest achieved up-to-date, as high as one-fourth of the theoretical maximum. The proposed method can be generally adapted to differentiate bio-enantiomers, paving the way to develop a wide range of chirality-related bio-applications.  
     
   
  Cite this article as:  
  Fan Bai, Wai-Fung Lau, Lin Yang, V. A. L. Roy, Zhifeng Huang, Dramatic enhancement of enantiomer differentiation induced by chiral nanoplasmons, Sci. Adv. Today 2 (2016) 25250.