Sci. Adv. Today 2 (2016) 25254  
  Review Article  
Potential of nanoparticles in cancer therapeutics: An insight  
  Nishi Mody, Rajeev Sharma and Suresh P. Vyas  
Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar, M.P., 470003, India
  Cancer is the second major cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of programmed cell death. While surgery and radiotherapy are the primary treatments used for local and nonmetastatic cancers, anti-cancer drugs (chemotherapy, hormone and biological therapies) are the choice currently used in metastatic cancers. Unfortunately, chemotherapy also affects normal cells especially those with fast proliferation rates, such as the hair follicles, bone marrow and gastrointestinal tract cells, generating the characteristic side effects of chemotherapy. The indiscriminate destruction of normal cells, the toxicity of conventional chemotherapeutic drugs, as well as the development of multidrug resistance, support the need to find new effective targeted treatments based on the molecular targets of the tumor cells. These novel targeted therapies includes nanoparticle mediated targeted drug delivery in order to specifically deliver chemotherapeutic agents to the cancer cells, vis a vis minimizing the undesirable side effects. Nanoparticles (NPs) are a group of nano-sized vehicles devised to deliver drugs to target malignant tissues or organs and have provided remarkably improved therapeutic efficacy for cancer therapy. A variety of NPs have been developed to accommodate efficient loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications of the surface or interior of NPs allow for modulation of pharmacokinetic features as per clinical demands. However, cancer-related mortality still remains high and drug-mediated cancer treatment a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy demonstrated and resulted from NPs. In this review, we focus on typical approaches and recent trends in NP-mediated drug delivery and their potential for targeted cancer therapy.  
  Cite this article as:  
  Nishi Mody, Rajeev Sharma and Suresh P. Vyas, Potential of nanoparticles in cancer therapeutics: An insight, Sci. Adv. Today 2 (2016) 25254.