Sci. Adv. Today 3 (2017) 25267  
  Research Article  
   
   
         
Designing nanostructured materials for photodynamic therapy: An update  
  Adimoolam G Mahesha, Amreddy Narsireddya,c, N. M. Raob and Sunkara V Manoramaa  
     
a Inorganic & Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, India
b CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500 007, India
c Stephenson Cancer Centre, OUHSC, Oklahoma City, USA

   
  Abstract  
  Despite global efforts towards understanding and managing cancer, the complexity and severity continues to baffle mankind. The ubiquitous nature of the disease defies all expectations and demands a multi-dimensional approach to address the problem. Among the various approaches that are being currently adopted for the treatment of cancer, Photodynamic therapy (PDT) is by far, one of the best options in terms of therapeutic efficiency and minimal side effects in treating atleast some types of cancers. PDT utilizes the ability of a photosensitizer (PS) to generate reactive oxygen species in the presence of light causing oxidative damage resulting in cell death. Designing appropriate PSs with nanocarriers is expected to improve the targeting ability and facilitate controlled release. It is further important to enhance the scope of the PDT by developing suitable PSs that absorb in the transparent region of the tissues and thereby facilitate PDT use in conjunction with other therapeutic strategies.  
     
   
  Cite this article as:  
  Adimoolam G Mahesh, Amreddy Narsireddy, N. M. Rao and Sunkara V Manorama, Designing nanostructured materials for photodynamic therapy: An update, Sci. Adv. Today 3 (2017) 25267.